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胡凯，主任医师、教授，博士、美国哈佛大学85po 眼科博士后、博士生导师、博士后合作导师；美国哈佛大学85po 附属麻省眼耳医院高级访问学者；85po 附属鼓楼医院眼科行政副主任。 临床与科研（基础研究）并举，均具有较丰富的经验；临床专业相对较全面，擅长对白内障、斜视、玻璃体视网膜及角膜眼表疾病的诊治及手术。曾在美国哈佛大学85po 附属麻省眼耳医院角膜病眼表专业从事博士后研究工作，目前长期从事单纯疱疹病毒性角膜炎（HSK）、干眼的研究工作，其中HSK方面至今在IOVS等期刊发表SCI论文近20篇，最高影响因子11.5，在国内该领域最多，处于国内领先；干眼方面发表SCI论文近15篇，其中4篇发表在IOVS。精通英语，能紧跟国际最新角膜眼表前沿及趋势，至今总共以第一作者或通讯作者发表SCI论文近50篇。主持角膜眼表相关研究课题如国家自然科学基金、江苏省自然科学基金、南京市卫生健康委员会重点项目、南京鼓楼医院临床专项等十多项，已获国家专利授权7项。在角膜眼表领域发表SCI文章及主持研究课题省内领先。 中华医学会眼科学分会眼免疫学组委员 中国医师协会眼科医师分会角膜病学组委员； 江苏省医学会眼科学分会常务委员； 南京市医学会眼科学分会委员； 国际泪膜与眼表学会中国区委员； 江苏省医学会眼科学分会斜视学组副组长 江苏省医师协会眼科医师分会基础研究与临床转化学组副组长； 美国眼科学与视觉科学研究协会会员； 国家自然科学基金评审专家； 教育部学位中心评审专家； 南京市紫金山英才高层次人才； 眼科权威期刊IOVS等多本SCI期刊审稿人； 眼科专业SCI期刊BMC Ophthalmology编委 *为通讯作者 1. Chengxiao Zhang, Yiran Chu, Yun He, Junwen Ouyang, Yaoyao Liu, Qian Wang, Youmei Zheng, Jiaxuan Jiang*, Kai Hu*（胡凯）. TIM-4 Blockade Upregulates NLRP3 to Activate the STING Pathway in Macrophages for the Treatment of Herpes Simplex Keratitis. Investigative Ophthalmology & Visual Science. 已接收.（2区，影响因子5.5） 2. Ruibo Chen, Tao Xu, Guorong Shi, Chunyan Xi, Mengqing Yin, Kai Hu*（胡凯）, Bing Chen*. 180-degree nuclear flip: a safety and efficacy assessment of a phacoemulsification technique for cataract nuclei of grade Ill and below. Ophthalmology and Therapy. 已接收.（3区，影响因子4.2） 3. Chengxiao Zhang, Zeying Chen, Jiaxuan Jiang, Junwen Ouyang, Kai Hu*（胡凯）. Efficacy of Sutureless and Glue-Free Conjunctival Autograft Compared with Sutured Conjunctival Autograft in Pterygium Surgery: A Meta-Analysis. Scientific Reports.2026 Jun 11. doi: 10.1038/s41598-026-54305-6. Epub ahead of print. （3区，影响因子4.9） 4. Junwen Ouyang, Yun He, Yaoyao Liu, Youmei Zheng, Changyu Wu, Jiaxuan Jiang*, Kai Hu*（胡凯）. HSV-1–Driven Lipid Metabolic Reprogramming and Lipid Droplet Accumulation in Macrophages Impair Antiviral Immunity.Investigative Ophthalmology & Visual Science. 2026 Jun 1;67(6):39.（2区，影响因子5.5） 5. Changyu Wu, Junwen Ouyang, Yaoyao Liu, Boxiao Zhao, Qian Wang, Junpeng Liu, Jiaxuan Jiang*,Kai Hu*（胡凯）. Time-Course Transcriptomic Analysis Reveals PANoptosis-CCL2 axis in Herpes Simplex Keratitis. Investigative Ophthalmology & Visual Science.2026 Jun 1;67(6):38.（2区，影响因子5.5） 6. Yiran Chu, Chengxiao Zhang, Zeying Chen, Qi Zhang, Yun Tang, Jiaxuan Jiang*, Kai Hu*（胡凯）. Therapeutic Effects of Glycyrrhizic Acid on Dry Eye Disease: Targeting Pyroptosis, Oxidative Stress, and Epithelial Barrier Dysfunction.International journal of molecular sciences. 2026 May 6;27(9):4153.（3区，影响因子5.6） 7. Yun Tang, Zeying Chen, Jiaxuan Jiang, Di Zhang, Yiran Chu, Boda Li, Qi Zhang, Kai Hu*（胡凯）. Inhibition of SGK1 alleviates apoptosis and oxidative stress in dry eye disease by activating FoxO3a-mediated autophagy.Investigative Ophthalmology & Visual Science.2026 May 1;67(5):37.（2区，影响因子5.5） 8. Di Zhang, Yun He, Fan Yang, Yiran Chu, Jiaxuan Jiang, Boda Li, Zeying Chen, Qi Zhang, Kai Hu*（胡凯）. SIRT3 mediates mitochondrial protection and attenuates mtROS-TXNIP-NLRP3 signaling activation in dry eye disease. Experimental Eye Research. 2026 Jun;267:110960.（2 区，影响因子 3.1） 9. Qi Liang, Zeying Chen, Yaoyao Liu, Rongjie Guo, Di Zhang, Jiaxuan Jiang*, Chenchen Wang*, Kai Hu*（胡凯）. Mechanistic Insights into UC-MSC Therapy in a BAC-Induced Dry Eye Model: TSG-6-Dependent Inhibition of the Th17/CCL20-CCR6 Chemotactic Axis. Investigative Ophthalmology & Visual Science. 2026 Apr 1;67(4):61.（2区，影响因子5.5） 10. Yun He, Yaoyao Liu, Junwen Ouyang, Chenchen Wang, Junpeng Liu, Changyu Wu, Qian Tan*, Jiaxuan Jiang*, Kai Hu*（胡凯）. IL-33-Driven Macrophage Reprogramming as a Potential Immunometabolic Strategy for Herpes Simplex Keratitis. Pharmaceuticals (Basel). 2026 Feb 8;19(2):285. （2 区，影响因子 5.7） 11. Zeying Chen, Yun Tang, Jiaxuan Jiang, Di Zhang, Yiran Chu, Boda Li, Qi Zhang, Huayong Zhang*, Kai Hu*（胡凯）. Inhibition of Histone Methyltransferase G9a Activates Autophagy and Provides Protection in Dry Eye Disease. Investigative Ophthalmology & Visual Science. 2025 Nov 3;66(14):52.（2区，影响因子5.5） 12. Jiao Liu, Rongjie Guo, Wenhao Shen, Jiaxuan Jiang, Yiran Chu, Changyu Wu, Kai Hu*（胡凯）. A Modified Swan Incision Combined with Lateral Rectus Suspension for Exotropia: A Retrospective Cohort Study Demonstrating Shorter Operative Time and Faster Recovery. Frontiers in Medicine. 2025 Sep 19;12:1571642.（3区，影响因子3.6） 13. Junpeng Liu, Wei Liu, Yefan Zhang, Junwen Ouyang, Boxiao Zhao, Changyu Wu, Boda Li, Jiaxuan Jiang*, Kai Hu*（胡凯）. Injectable High-Adhesion Fibrinogen-Silk Fibroin Hydrogel Loaded with Curcumin Accelerates Pterygium Repair via Dual Anti-Inflammatory/Antiproliferative Mechanisms. ACS Applied Materials & Interfaces. 2025 Sep 17;17(37):51805-51819.（2区，影响因子7.8） 14. Junwen Ouyang, Changyu Wu, Jingya Yang, Yun He, Junpeng Liu, Boxiao Zhao, Youmei Zheng, Boda Li, Jiaxuan Jiang*, Kai Hu*（胡凯）. Suppression of MERTK Inhibits Proliferation and Migration of Pterygium Fibroblasts. Experimental Eye Research. 2025 Nov;260:110595.（2 区，影响因子 3.1） 15. Yun He, Di Zhang, Jiao Liu, Junwen Ouyang, Chengxiao Zhang, Qian Tan*, Jiaxuan Jiang*, Kai Hu*（胡凯）. Ocular Soluble Microneedle Patch Loaded with Immunogenic Cell Death Inducer PKHB1 Peptide for Alleviating Herpes Simplex Keratitis.ACS Applied Materials & Interfaces.2025;17(30):42824-42837.（2区，影响因子7.8） 16. Junpeng Liu, Boda Li, Boxiao Zhao, Wei Liu, Fan Yang, Jingya Yang, Jiaxuan Jiang*, Kai Hu*（胡凯）. IL-33 alleviates corneal nerve damage in herpes simplex keratitis. International Immunopharmacology. 2025 Jun 26:159:114833.（2区，影响因子5.6） 17. Ruibo Chen, Tao Xu, Chunyan Xi, Kejun Liu, Kai Hu*（胡凯）, Bing Chen*. An applied study of phacoemulsification cataract surgery with the mortise and tenon limbal incision.Scientific reports. 2025 Jun 3;15(1):19464. （3区，影响因子4.2） 18. Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang*, Kai Hu*（胡凯）. A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry eye disease. Stem cell research & therapy. 2025 Apr 23;16(1):202.（2区，影响因子7.8） 19. Di Zhang, Qi Liang, Jiaxuan Jiang, Wei Liu, Yiran Chu, Zeying Chen, Boda Li, Taige Chen, Jia-Ruei Tsao, Kai Hu*（胡凯）. SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1. Experimental Eye Research. 2025 Mar 8;254:110328.（2区，影响因子3.1） 20. Boda Li, Junpeng Liu, Di Zhang, Yiran Chu, Zeying Chen, Jiaruei Tsao, Taige Chen, Jiaxuan Jiang*, Kai Hu*（胡凯）. Evodiamine promotes autophagy and alleviates oxidative stress in dry eye disease through the p53-mTOR pathway. Investigative Ophthalmology & Visual Science. 2025 Mar 3;66(3):44.（2区，影响因子5.5） 21. Boda Li, Jiaxuan Jiang, Qi Zhang, Yiran Chu, Zeying Chen, Kai Hu*（胡凯）.Therapeutic effects of umbilical cord serum for dry eye disease: a systemic review and meta-analysis. Ophthalmic Research. 2024 Dec 2;68(1):71–83.（3区，影响因子1.900） 22. Jiaxuan Jiang, Di Zhang, Wei Liu, Jingya Yang, Fan Yang, Junpeng Liu, Kai Hu*（胡凯）.Overexpression of NLRP12 enhances macrophage immune response and alleviates herpes simplex keratitis. Frontiers in Cellular and Infection Microbiology. 2024 Jul 25;14:1416105.（2区，影响因子4.800） 23. Jiaxuan Jiang, Wenhao Shen, Yun He, Junpeng Liu, Junwen Ouyang, Chengxiao Zhang, Kai Hu*（胡凯）. Overexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-γ signaling. International immunopharmacology. 2024 Aug 20;137:112428.（2区，影响因子4.700） 24. Taige Chen, Nan Zhou, Qi Liang, Qi Li, Boda Li, Yiran Chu, Di Zhang, Zeying Chen, Jia-Ruei Tsao, Xuebing Feng*, Kai Hu*（胡凯）.Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease. European Journal of Pharmacology. 2024 Aug 15;977:176583.（2区，影响因子4.700） 25. Zeying Chen, Chengxiao Zhang, Jiaxuan Jiang, Junwen Ouyang, Di Zhang, Taige Chen, Yiran Chu, Kai Hu*（胡凯）. The Efficacy of Vitamin D Supplementation in Dry Eye Disease: A Systematic Review and Meta-Analysis. Contact Lens and Anterior Eye. 2024 Oct;47(5):102169.（3区，影响因子3.700） 26. Nan Zhou, Taige Chen, Qiao You, Deyan Chen, Lifei Liu*, Kai Hu*（胡凯）. Enterovirus A71 infection-induced dry eye-like symptoms by damaging the lacrimal glands. Frontiers in Cellular and Infection Microbiology.2024 Apr 2;14:1340075.（2区，影响因子4.800） 27. Wenhao Shen, Chenchen Wang, Jiaxuan Jiang, Yun He, Qi Liang, Kai Hu*（胡凯）. Targeted delivery of herpes simplex virus glycoprotein D to CD169+ macrophages using ganglioside liposomes alleviates herpes simplex keratitis in mice. Journal of Controlled Release. 2024 Jan;365:208-218.（1区，影响因子11.500） 28. Rongjie Guo, Jiaxuan Jiang, Yanan Zhang, Qi Liang, Jiao Liu, Kai Hu*（胡凯）. The effects of chalazion and the excision surgery on the ocular surface. Heliyon. 2023 Sep 9;9(9):e19971.（3区，影响因子4.000） 29. Nan Zhou, Deyuan Zheng, Qiao You, Taige Chen, Jiaxuan Jiang, Wenhao Shen, Di Zhang, Junpeng Liu, Deyan Chen*, Kai Hu*（胡凯）. Therapeutic Potential of Biochanin A in Herpes Simplex Keratitis. Pharmaceuticals （Basel）. 2023 Sep 1;16(9):1240.（3区，影响因子4.600） 30. Qi Liang, Rongjie Guo, Jia-Ruei Tsao, Yun He, Chenchen Wang, Jiaxuan Jiang, Di Zhang, Taige Chen, Tingting Yue*, Kai Hu*（胡凯）. Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway. International Immunopharmacology. 2023 Aug;121:110397.（2区，影响因子5.600） 31. Rongjie Guo, Jiaxuan Jiang, Yanan Zhang, Qi Liang, Taige Chen, Kai Hu*（胡凯）. Evaluation of corneal dendritic cell density and subbasal nerve density in contact lens wearers using IVCM: A systematic review and meta-analysis. Frontiers in Medicine. 2023 Mar 13;10:1149803.（3区，影响因子3.900） 32. Rongjie Guo, Qi Liang, Yun He, Chenchen Wang, Jiaxuan Jiang, Taige Chen, Di Zhang, Kai Hu*（胡凯）. Mesenchymal stromal cells-derived extracellular vesicles regulate dendritic cell functions in dry eye disease. Cells.2022 Dec 22;12(1):33.（2区，影响因子6.000） 33. Yun He, Chenchen Wang, Qi Liang, Rongjie Guo, Jiaxuan Jiang, Wenhao Shen, Kai Hu*（胡凯）. PKHB1 Peptide Induces Antiviral Effects Through Induction of Immunogenic Cell Death in Herpes Simplex Keratitis. Frontiers in Pharmacology.2022 Dec 1;13:1048978.（2区，影响因子5.600） 34. Qin Qin*, Kai Hu（胡凯）, Zifang He, Feifei Chen, Wenwen Zhang, Yajun Liu, Zhenggao Xie*. Resolvin D1 protects against Aspergillus fumigatus keratitis in diabetes by blocking the MAPK-NF-κB pathway. Experimental Eye Research. 2022 Mar;216:108941.（2区，影响因子3.400，共同第一） 35. Chenchen Wang, Qi Liang, Dong Sun, Yun He, Jiaxuan Jiang, Rongjie Guo, Tejsu Malla, Pedram Hamrah, Xun Liu, Zhenping Huang*, Kai Hu*（胡凯）. Nectin-1 and Non-muscle Myosin Heavy Chain-ⅡB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves. Frontiers in Microbiology. 2022 Feb 28;13:830699.（2区，影响因子5.200） 36. Arsia Jamali, Kai Hu（胡凯） Victor G Sendra, Tomas Blanco, Maria J Lopez, Gustavo Ortiz, Yureeda Qazi, Lixin Zheng, Aslihan Turhan, Deshea L Harris, Pedram Hamrah*. Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis. Cell Reports. 2020 Sep 1;32(9):108099.（1区，影响因子8.800，共同第一，Cell子刊） 1. 江苏省自然科学基金（BK20241725，2025.1-2027.12）：IL-33防治复发性HSK的机制研究；15万；项目负责人。（在研） 2. 2024年度江苏省概念验证中心——南京鼓楼医院专项资金拟资助项目（2024.10-2027.9）：一种高效检查眼表病变的激光共聚焦显微镜智能调节系统转化研究；10万；项目负责人。（在研） 3. 南京鼓楼医院临床专项（2022-LCYJ-MS-36，2022.7-2025.6）：间充质干细胞滴眼液治疗干眼病的临床研究；50万；项目负责人。（结题） 4. 南京市卫生健康委员会一般性课题（YKK21095，2022-2024），间充质干细胞悬液滴眼治疗干眼病及其机制研究；3万；项目负责人。（结题） 5. 国家自然科学基金面上项目（81870695，2019-2022）：激发巨噬细胞的抗复发性HSK新型DNA疫苗研制及免疫机制研究；61万；项目负责人。（已结题） 6. 江苏省自然科学基金（BK20201114，2021-2023）：介导单纯疱疹病毒侵入眼角膜神经的细胞受体及侵入机制研究；10万；项目负责人。（已结题） 7. 南京市卫生健康委员会重点项目（ZKX20022，2021-2023）：Nectin-1和NMHC-IIB在HSV-1眼部感染致潜伏中的作用研究；10万；项目负责人。（已结题） 8. 江苏省卫计委医学科研课题（Z2018034，2019-2020）：新型DNA疫苗防治复发性HSK及其机制研究；5万；项目负责人。（已结题） 9. 中央高校基本科研业务费专项资金资助课题（021414380367，2018-2019）：激发巨噬细胞的抗复发性HSK新型DNA疫苗研制及免疫机制研究；10万；项目负责人。（已结题） 10. 南京市医学科技发展课题（YKK16107，2017-2019）：DNA疫苗pRSC-gD•gC-IL-21的研制及眼表滴种治疗复发性HSK的研究；10万；项目负责人。（已结题） 11. 江苏省自然科学基金（BK20141346，2014-2017）：新型靶向DC的DNA纳米疫苗治疗复发性HSK的实验研究；项目负责人。（已结题） 12. 南京市科技发展计划（201402001，2014-2017）：眼表滴种靶向DC的纳米pRSC-NLDC145•gD-IL-21 DNA疫苗治疗复发性HSK的研究；项目负责人。（已结题） 13. 美国NIH R01课题（1R01EY022695-01A1，2012-2018）：The Role of Plasmacytoid Dendritic Cells in Corneal Immunity；共同研究者（co-investigator）。（已结题） 已获授权国家发明专利3项（ZL201510362141.2；ZL201510362541.3；202220036909.7）；国家实用新型专利4项（202421511463.X；2022 2 2480709.9；3220644383.1；202321662753X）。 2021年南京市紫金山英才高层次人才。 |
